The pulse of chemistry is synthesis. Its mission is the exploration of new compounds with unique structures and novel properties. We seek to develop functional molecular materials for advancing applications in energy conversion, catalysis, gas storage and separation, sensing, photonics and microelectronics. To illustrate, metal-rich complexes, atomic precise clusters, nanoparticles and nanocomposites of abundant metals can substitute rare noble metals for catalytic transformation of small molecules. In addition, the combinatorial building-block principle of metal-organic frameworks (MOFs) yields ample opportunities for the manipulation and design of their functionality e.g. the chemistry of coordination space in pores and channels accessible to guest molecules. Our aim is to integrate chemical and physical multifunctionality in photo active, conductive, catalytic and stimuli-responsive MOFs.